Blood management expert Jerrold Levy, MD, FAHA, addresses questions concerning today's therapeutic options for achieving and maintaining intraoperative hemostasis. As part of this activity, Dr. Levy discusses current recommendations for selecting topical agents and the value of hemostatic tests both inside and outside of the OR. Additional topics discussed by Dr. Levy include the clinical significance of acquired coagulopathy secondary to bovine thrombin exposure, individual dynamics that may predispose a patient to intraoperative bleeding, and the challenges of maintaining hemostasis in the surgical setting.